Kidney disease impairs B cells response against infection via inhibiting germinal center formation and antibody titers
نویسندگان
چکیده
Abstract Immunity to infections is crucial healthy life. However, recent Covid-19 pandemic has shown that comorbidity such as kidney disease and associated uremia impairs immunity against infections. Uremic patients show high susceptible also exhibit poor antibody responses vaccine. The mechanisms by which negatively impacts response unknown. Using multiple mouse models of uremia, we assessed B cells model antigen NP-KLH in alum. We inhibits both canonical germinal center (GC) non-canonical extra-follicular following immunization. Immunized uremic mice demonstrated compromised affinity maturation, isotype switching, antigen-specific secreting cells, titer T follicular helper response. Consequently, exhibited diminished GC prime-boost showed increased cell cycle arrest, apoptosis impaired migration between light dark zone the GCs. identified toxin hippuric acid a major driver loss mitochondrial membrane potential leading human cells. Finally, were similarly during influenza virus infection, cause mortality with disease. These results shed on how toxin(s) suppress antimicrobial vaccine individuals Knowledge gained from this study may pave path for developing effective therapeutic preventive strategies including SARS-CoV-2. R01AI142354, R01AI162616 R21AI159058
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ژورنال
عنوان ژورنال: Journal of Immunology
سال: 2023
ISSN: ['1550-6606', '0022-1767']
DOI: https://doi.org/10.4049/jimmunol.210.supp.76.01